Title of article
Synthesis of fluorescent derivatives of wortmannin and demethoxyviridin as probes for phosphatidylinositol 3-kinase
Author/Authors
José-Luis Giner، نويسنده , , Karen A Kehbein، نويسنده , , James A. Cook، نويسنده , , Michele C. Smith، نويسنده , , Chris J. Vlahos، نويسنده , , John A. Badwey، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
2518
To page
2521
Abstract
Fluorescent analogs were synthesized of the potent PI 3-kinase inhibitors, wortmannin and demethoxyviridin. The esterification of 11-deacetylwortmannin, 17-hydroxywortmannin, and demethoxyviridin with the fluorescent carboxylic acids NBD-sarcosine and 7-dimethylaminocoumarin-4-acetic acid generated six novel fluorescent esters. Potent inhibition of PI 3-kinase-α was observed for the derivatives of 11-desacetylwortmannin and demethoxyviridin.
Keywords
fluorescent probes , Steroidal drugs , Phosphoinositol 3-kinase , Enzyme inhibitors
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796814
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