Author/Authors :
Erich L. Grimm، نويسنده , , Christine Brideau، نويسنده , , Nathalie Chauret، نويسنده , , Chi-Chung Chan، نويسنده , , Daniel Delorme، نويسنده , , Yves Ducharme، نويسنده , , Diane Ethier، نويسنده , , Jean-Pierre Falgueyret، نويسنده , , Richard W. Friesen، نويسنده , , Jocelyne Guay، نويسنده , , Pierre Hamel، نويسنده , , Denis Riendeau، نويسنده , , Chantal Soucy-Breau، نويسنده , , Philip Tagari، نويسنده , , Jean-Yves Girard، نويسنده ,
Abstract :
Leukotriene biosynthesis inhibitors have potential as therapeutic agents for asthma and inflammatory diseases. A novel series of substituted coumarin derivatives has been synthesized and the structure–activity relationship was evaluated with respect to their ability to inhibit the formation of leukotrienes via the human 5-lipoxygenase enzyme.
Keywords :
5-lipoxygenase , Leukotrienene inhibitor , coumarin , structure–activity relationship
