Title of article
(R)-Sila-venlafaxine: A selective noradrenaline reuptake inhibitor for the treatment of emesis
Author/Authors
Graham A. Showell، نويسنده , , Matthew J. Barnes، نويسنده , , Jürgen O. Daiss، نويسنده , , John S. Mills، نويسنده , , John G. Montana، نويسنده , , Reinhold Tacke، نويسنده , , Julie BH Warneck، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
2555
To page
2558
Abstract
Sila-substitution of drugs (the carbon/silicon switch) is a concept that is being successfully used for the development of new chemical entities. The (R)-sila-analogue of the antidepressant venlafaxine is devoid of the serotonin reuptake inhibition observed with the marketed drug, leading to a selective noradrenaline reuptake inhibitor displaying anti-emetic properties.
Keywords
Noradrenaline reuptake inhibitor , Anti-emetic , Sila-substitution
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796823
Link To Document