Title of article :
Novel 4-anilinoquinazolines with C-6 carbon-linked side chains: Synthesis and structure–activity relationship of a series of potent, orally active, EGF receptor tyrosine kinase inhibitors
Author/Authors :
Laurent F.A. Hennequin، نويسنده , , Peter Ballard، نويسنده , , F. Tom Boyle، نويسنده , , Bénédicte Delouvrié، نويسنده , , Rebecca P.A. Ellston، نويسنده , , Chris T. Halsall، نويسنده , , Craig S. Harris، نويسنده , , Kevin Hudson، نويسنده , , Jane Kendrew، نويسنده , , J. Elizabeth Pease، نويسنده , , Helen S. Ross، نويسنده , , Peter Smith، نويسنده , , Jennifer L. Vincent، نويسنده ,
Abstract :
The structure–activity relationship of a novel subseries of 4-anilinoquinazoline EGFR inhibitors substituted at the C-6 position with carbon-linked side chains has been investigated. This exploration has led to the discovery of novel aminomethyl carboxamides with good biological, pharmacokinetic and physical properties.
