Title of article
N-Benzylbenzamides: A new class of potent tyrosinase inhibitors
Author/Authors
Sung Jin Cho، نويسنده , , Jung Seop Roh، نويسنده , , Won Suck Sun، نويسنده , , Sung-Han Kim، نويسنده , , Ki Duk Park، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
3
From page
2682
To page
2684
Abstract
A series of potent inhibitors of tyrosinase and their structure–activity relationships are described. N-Benzylbenzamide derivatives (1–21) with hydroxyl(s) were synthesized and tested for their tyrosinase inhibitory activity. With this series, compound 15 provided a potent tyrosinase inhibition: it effectively inhibited the oxidation of l-DOPA catalyzed by mushroom tyrosinase with an IC50 of 2.2 μM.
Keywords
N-Benzylbenzamides , Tyrosinase inhibitor , SAR , 4-Substituted resorcinol
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796847
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