Title of article
Arylanthranilodinitriles: A new biaryl class of antileishmanial agents
Author/Authors
Fateh V. Singh، نويسنده , , Rit Vatsyayan، نويسنده , , Uma Roy، نويسنده , , Atul Goel، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
2734
To page
2737
Abstract
A series of anthranilodinitrile-based biaryls were synthesized and evaluated in vitro against extracellular promastigotes and intracellular amastigotes of Leishmania donovani. Among various screened compounds, a biaryl with trifluoromethyl group 5f showed 83% inhibition against promastigotes and 70% inhibition against amastigotes of L. donovani at 8 and 20 μg/mL concentrations, respectively.
Keywords
Leishmaniasis , Anthranilodinitrile , Biaryls , Amastigotes , promastigotes
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796858
Link To Document