Title of article
Vasorelaxant activity of phthalazinones and related compounds
Author/Authors
Esther del Olmo، نويسنده , , Bianca Barboza، نويسنده , , M Inés Ybarra، نويسنده , , José Luis L?pez-Pérez، نويسنده , , Rosal?a Carr?n، نويسنده , , M Angeles Sevilla، نويسنده , , Cinthia Boselli، نويسنده , , Arturo San Feliciano، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
2786
To page
2790
Abstract
Several series of dihydrostilbenamide, imidazo[2,1-a]isoindole, pyrimido[2,1-a]isoindole and phthalazinone derivatives were obtained and their vasorelaxant activity was measured on isolated rat aorta rings pre-contracted with phenylephrine (10−5 M). Some phthalazinones attained, practically, the total relaxation of the organ at micromolar concentrations. For the most potent compound 9h (EC50 = 0.43 μM) the affinities for α1A, α1B and α1D adrenergic sub-receptors were determined.
Keywords
Dihydrostilbenamide , Phthalazinone , ?1A , Rat aorta rings , ?1B and ?1D sub-receptors affinity , Vasorelaxant activity
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796870
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