Title of article
DNA hydrolysis promoted by 1,7-dimethyl-1,4,7,10-tetraazacyclododecane
Author/Authors
Shuhui Wan، نويسنده , , Feng Liang، نويسنده , , Xiao-Qin Xiong، نويسنده , , Li Yang، نويسنده , , Xiaojun Wu، نويسنده , , Ping Wang، نويسنده , , Xiang Zhou، نويسنده , , Chengtai Wu، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
3
From page
2804
To page
2806
Abstract
Several acyclic and macrocyclic polyamines were evaluated for their ability to cleave DNA. 1,7-Dimethyl-1,4,7,10-tetraazacyclododecane (DMC) could hydrolyze double-strand DNA at a concentration of 25 μM. pH 7.2 was the optimal condition to cleave DNA in the presence of DMC. Supercoiled DNA hydrolytic cleavage by DMC was supported by the evidence from free radical quenching and T4 ligase ligation.
Keywords
Macrocyclic polyamine , DNA cleavage , ligation
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796874
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