Title of article
The search for novel TRPV1-antagonists: From carboxamides to benzimidazoles and indazolones
Author/Authors
Stephen Robert Fletcher، نويسنده , , Edward McIver، نويسنده , , Stephen Lewis، نويسنده , , Frank Burkamp، نويسنده , , Clare Leech، نويسنده , , Glenn Mason، نويسنده , , Susan Boyce، نويسنده , , Denise Morrison، نويسنده , , Gillian Richards، نويسنده , , Kathy Sutton، نويسنده , , Anthony Brian Jones، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
2872
To page
2876
Abstract
Based on a series of diaryl amides the corresponding inverse amides have been found to be potent TRPV1 receptor antagonists. Benzimidazole and indazolone derivatives prepared retained good potency in vitro and indazolone 4a was identified as a novel TRPV1 receptor antagonist suitable for evaluating orally in animal models of analgesia.
Keywords
TRPV-1 antagonists , Indazolone , Benzimidazole
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796887
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