Title of article
Synthetic analogues of the manzamenones and plakoridines which inhibit DNA polymerase
Author/Authors
Jeremy R. Doncaster، نويسنده , , Laura L. Etchells، نويسنده , , Neil M. Kershaw، نويسنده , , Ryoichi Nakamura، نويسنده , , Hazel Ryan، نويسنده , , Ryo Takeuchi، نويسنده , , Kengo Sakaguchi، نويسنده , , Ali Sardarian، نويسنده , , Roger C. Whitehead، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
2877
To page
2881
Abstract
An array of novel analogues of the marine oxylipins, the manzamenones and plakoridines, have been prepared in divergent fashion using an approach modelled on a biogenetic theory. Many of the target compounds show potent inhibition of DNA polymerases α and β and human terminal deoxynucleotidyl transferase (TdT).
Keywords
biomimetic synthesis , Oxylipins , natural products , DNA polymerase
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796888
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