Title of article
Development of new simple molecular probes of DNA bulged structures
Author/Authors
Ziwei Xiao، نويسنده , , Lizzy S. Kappen، نويسنده , , Irving H. Goldberg، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
2895
To page
2899
Abstract
NCSi-gb is a neocarzinostatin chromophore (NCS-chrom) metabolite which binds strongly to certain two-base DNA bulges. Compared with previously reported NCSi-gb analogues, a new analogue with a different aminoglycoside position was synthesized, and it showed strong fluorescence and improved binding and sequence selectivity to DNA bulges. The N-dimethylated form of this analogue had a similar binding pattern, and it competitively inhibited bulge-specific cleavage by NCS-chrom.
Keywords
DNA bulge binding , DDI , NCSi-gb analogues , fluorescence
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796892
Link To Document