Title of article
Two novel aromatic valerenane-type sesquiterpenes from the Chinese green alga Caulerpa taxifolia
Author/Authors
Shui-Chun Mao، نويسنده , , Yue-Wei Guo، نويسنده , , Xu Shen، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
2947
To page
2950
Abstract
Caulerpal A (2) and B (3), two novel sesquiterpenes possessing an uncommon aromatic valerenane-type carbon skeleton, along with one known metabolite, caulerpin (4), have been isolated from the Chinese green alga Caulerpa taxifolia (Vahl) C. Agardh. Their structures and relative stereochemistry were elucidated on the basis of extensive spectroscopic analysis. Compounds 2–4 were evaluated for their inhibitory activity against hPTP1B and the result showed that only compound 4 had a strong PTP1B inhibitory activity with an IC50 value of 3.77 μM.
Keywords
Green alga , Caulerpa taxifolia , Aromatic valerenane-type sesquiterpenes , Caulerpal A and B
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796903
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