Title of article :
Synthesis and evaluation of a mechanism-based inhibitor of a 3-deoxy-d-arabino heptulosonate 7-phosphate synthase
Author/Authors :
Scott R. Walker، نويسنده , , Emily J. Parker، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Abstract :
The first mechanism-based inhibitor of a 3-deoxy-d-arabino heptulosonate 7-phosphate (DAH7P) synthase has been synthesised in 12 steps from d-arabinose, and has been found to be a very slow binding inhibitor of Escherichia coli DAH7P synthase.
Keywords :
DAHP , shikimate , DAH7P , Transition-state inhibitor
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
