Title of article :
1,3,5-Trisubstituted aryls as highly selective PPARδ agonists
Author/Authors :
Robert Epple، نويسنده , , Mihai Azimioara، نويسنده , , Ross Russo، نويسنده , , Badry Bursulaya، نويسنده , , Shin-Shay Tian، نويسنده , , Andrea Gerken، نويسنده , , Maya Iskandar، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Abstract :
A series of highly potent and selective PPARδ agonists is described using the known non-selective ligand GW2433 as a structural template. Compound 1 is bioavailable, potent (10 nM), and shows no cross-activity with other PPAR subtypes up to 10 μM, making it a useful tool in studying the biological effects of selective PPARδ activation.
Keywords :
Nuclear receptors , Peroxisome proliferator-activated receptor delta , Virtual docking , PPAR agonists
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
