Title of article :
Synthesis and preliminary antitumor activity evaluation of a DHA and doxorubicin conjugate
Author/Authors :
Yuqiang Wang، نويسنده , , Lianfa Li، نويسنده , , Wei Jiang، نويسنده , , Zhaoqi Yang، نويسنده , , Zaijun Zhang، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Abstract :
A conjugate of DHA and doxorubicin (DHA–Dox) was synthesized, and its antitumor activity was evaluated in vitro against L1210 leukemia cells and in experimental animal tumor models including L1210 leukemia and B16 melanoma. DHA–Dox showed a greatly improved antitumor efficacy compared to free doxorubicin.
Keywords :
doxorubicin , drug delivery , Anticancer , DHA
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
