Title of article
Synthesis and biological evaluation of rhodanine derivatives as PRL-3 inhibitors
Author/Authors
Jin-Hee Ahn، نويسنده , , Seung Jun Kim، نويسنده , , Woul Seong Park، نويسنده , , Sung Yun Cho، نويسنده , , Jae Du Ha، نويسنده , , Sung-Soo Kim، نويسنده , , Seung Kyu Kang، نويسنده , , Dae Gwin Jeong، نويسنده , , Suk-Kyeong Jung، نويسنده , , Sang-Hyeup Lee، نويسنده , , Hwan-Mook Kim، نويسنده , , Song Kyu Park، نويسنده , , Ki Ho Lee، نويسنده , , Chang Woo Lee، نويسنده , , Seong-Eon Ryu، نويسنده , , Joong-Kwon Choi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
2996
To page
2999
Abstract
A series of rhodanine derivatives was synthesized and evaluated for their ability to inhibit PRL-3. Benzylidene rhodanine derivative showed good biological activity, while compound 5e was the most active in this series exhibiting an IC50 value of 0.9 μM in vitro and showed a reduced invasion in cell-based assay.
Keywords
Rhodanine , cancer , metastasis , inhibitor , PRL-3
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796914
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