• Title of article

    SAR studies: Designing potent and selective LXR agonists

  • Author/Authors

    Jason W. Szewczyk، نويسنده , , Shaei Huang، نويسنده , , Jayne Chin، نويسنده , , Jenny Tian، نويسنده , , Lyndon Mitnaul، نويسنده , , Raymond L. Rosa، نويسنده , , Larry Peterson، نويسنده , , Carl P. Sparrow، نويسنده , , Alan D. Adams، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2006
  • Pages
    6
  • From page
    3055
  • To page
    3060
  • Abstract
    Counterscreening compounds from a Merck PPAR program discovered lead 1, as a nanomolar LXR/PPAR dual agonist. SAR optimization developed a series of heterocyclic LXR agonists having excellent selectivity over all PPAR isoforms and possessing high LXR affinity and strong in vivo potency.
  • Keywords
    SAR study , Small molecule agonist , LXR
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Serial Year
    2006
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Record number

    796926

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=796926