Title of article
Diarylacetylene piperidinyl amides as novel anxiolytics
Author/Authors
Cheryl P. Kordik، نويسنده , , Chi Luo، نويسنده , , Maryann Gutherman، نويسنده , , Anil H. Vaidya، نويسنده , , Daniel I. Rosenthal، نويسنده , , Jeffrey J. Crooke، نويسنده , , Sandra L. McKenney، نويسنده , , Carlos R. Plata-Salamàn، نويسنده , , Allen B. Reitz، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
3
From page
3065
To page
3067
Abstract
N-Phenyl-2-[1-[3-(2-pyridinylethynyl)benzoyl]-4-piperidine]acetamide (9) and related piperidine acetamide derivatives have good oral activity in the elevated plus maze, an animal model predictive of clinical efficacy for the treatment of anxiety. Modest affinity was observed for the neurokinin NK-1 and 2 receptors, which are known to be involved in the regulation of mood and emotion.
Keywords
Neurokinin , elevated plus maze , Sonogashira coupling , Diarylacetylenes , piperidines , Anxiolytics
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796928
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