Title of article :
Suzuki-type Pd(0) coupling reactions in the synthesis of 2-arylpurines as Cdk inhibitors
Author/Authors :
Lucie Vandromme، نويسنده , , Sandrine Piguel، نويسنده , , Olivier Lozach، نويسنده , , Laurent Meijer، نويسنده , , Michel Legraverend، نويسنده , , David S. Grierson and Robert W. Carpick، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Abstract :
A new series of 2-aryl-substituted purine derivatives has been synthesized by Suzuki Pd(0) coupling reactions. Moderate in vitro inhibitory activity against Cdk1 and Cdk5 was observed. These compounds are inactive against GSK3.
Keywords :
Purine , CDK , inhibitors , Suzuki cross-coupling
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
