Title of article :
Synthesis of 2-alkoxy-8-hydroxyadenylpeptides: Towards synthetic epitope-based vaccines
Author/Authors :
Jimmy J. Weterings، نويسنده , , Selina Khan، نويسنده , , Gerbrand J. van der Heden، نويسنده , , Jan W. Drijfhout، نويسنده , , Cornelis JM Melief، نويسنده , , Herman S. Overkleeft، نويسنده , , Sjoerd H. van der Burg، نويسنده , , Ferry Ossendorp، نويسنده , , Gijsbert A. van der Marel، نويسنده , , Dmitri V. Filippov، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Pages :
4
From page :
3258
To page :
3261
Abstract :
The preparation of three different 2-alkoxy-8-hydroxyadenylpeptide conjugates has been accomplished by solid-phase synthesis combined with ‘on-resin’ Cu(I) catalyzed Huisgen cycloaddition. The immunogenicity of the compounds has been evaluated in IL-12 production and antigen presentation assays.
Keywords :
TLR-7 , Peptide synthesis , Huisgen cycloaddition , dendritic cells , Antigen presentation
Journal title :
Bioorganic & Medicinal Chemistry Letters
Serial Year :
2006
Journal title :
Bioorganic & Medicinal Chemistry Letters
Record number :
796969
Link To Document :
https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=796969
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