Title of article
Substituted pyrrolidine-2,4-dicarboxylic acid amides as potent dipeptidyl peptidase IV inhibitors
Author/Authors
Ting-Yueh Tsai، نويسنده , , Mohane Selvaraj Coumar، نويسنده , , Tsu Hsu، نويسنده , , Hsing-Pang Hsieh، نويسنده , , Chia-Hui Chien، نويسنده , , Chiung-Tong Chen، نويسنده , , Chung-Nien Chang، نويسنده , , Yu-Kang Lo، نويسنده , , Ssu-Hui Wu، نويسنده , , Chung-Yu Huang، نويسنده , , Yu-Wen Huang، نويسنده , , Min-Hsien Wang، نويسنده , , Hsin-Yi Wu، نويسنده , , Hong-Jen Lee، نويسنده , , Xin Chen، نويسنده , , Yu-Sheng Chao، نويسنده , , Weir-Torn Jiaang، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
3268
To page
3272
Abstract
A series of substituted pyrrolidine-2,4-dicarboxylic acid amides were synthesized as potential antidiabetic agents, and many of them showed good in vitro DPP-IV inhibition (IC50 = 2–250 nM) with selectivity over DPP-II, DPP8, and FAP enzymes. Selected compounds 8c and 11a showed in vivo plasma DPP-IV inhibition after oral administration in Wistar rats.
Keywords
DPP-IV , pyrrolidine , Diabetes
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796971
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