Title of article :
Inhibitory activity of cyclohexenyl chalcone derivatives and flavonoids of fingerroot, Boesenbergia rotunda (L.), towards dengue-2 virus NS3 protease
Author/Authors :
Tan Siew Kiat، نويسنده , , Richard Pippen، نويسنده , , Rohana Yusof، نويسنده , , Halijah Ibrahim، نويسنده , , and Norzulaani Khalid، نويسنده , , Noorsaadah Abd Rahman، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Abstract :
Boesenbergia rotunda (L.) cyclohexenyl chalcone derivatives, 4-hydroxypanduratin A and panduratin A, showed good competitive inhibitory activities towards dengue 2 virus NS3 protease with the Ki values of 21 and 25 μM, respectively, whilst those of pinostrobin and cardamonin were observed to be non-competitive. NMR and GCMS spectroscopic data formed the basis of assignment of structures of the six compounds isolated.
Keywords :
Cyclohexenyl chalcone derivatives , Dengue 2 , NS3 protease , Competitive inhibitory activities , Boesenbergia rotunda (L.) extracts
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
