Title of article
Synthesis and SAR of 1,3-disubstituted cyclohexylmethyl urea and amide derivatives as non-peptidic motilin receptor antagonists
Author/Authors
Sigmond G. Johnson، نويسنده , , Joseph W. Gunnet، نويسنده , , John B. Moore، نويسنده , , William Miller، نويسنده , , Pam Wines، نويسنده , , Ralph A. Rivero، نويسنده , , Don Combs، نويسنده , , Keith T. Demarest، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
3362
To page
3366
Abstract
A series of 1,3-disubstituted cyclohexylmethyl urea and amide derivatives were synthesized as motilin receptor antagonists. Starting from known motilin antagonists, 1a and 1b, the cyclopentene scaffold was replaced and the four recognition elements optimized to arrive at a potent novel series.
Keywords
Motilin , Antagonist
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796990
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