Title of article :
The neuroprotective activity of GPE tripeptide analogues does not correlate with glutamate receptor binding affinity
Author/Authors :
Sergio A. Alonso De Diego، نويسنده , , Marta Gutiérrez-Rodr?guez، نويسنده , , M. Jes?s Pérez de Vega، نويسنده , , Rosario Gonz?lez-Mu?iz، نويسنده , , Rosario Herranz، نويسنده , , Mercedes Mart?n-Mart?nez، نويسنده , , Edurne Cenarruzabeitia، نويسنده , , Diana Frechilla، نويسنده , , Joaqu?n Del R?o، نويسنده , , M. Luisa Jimeno، نويسنده , , M. Teresa Garc?a-L?pez، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Pages :
5
From page :
3396
To page :
3400
Abstract :
The influence of several modifications on the GPE tripeptide structure upon the binding to GluRs and on their neuroprotective effects has been studied. The results indicated that the prevention of neuronal death showed by GPE and some analogues is not directly related to their affinity at glutamate receptors.
Keywords :
peptidomimetics , neuroprotection , Glutamate receptors binding , GPE , Tripeptides
Journal title :
Bioorganic & Medicinal Chemistry Letters
Serial Year :
2006
Journal title :
Bioorganic & Medicinal Chemistry Letters
Record number :
796998
Link To Document :
بازگشت