Title of article
The neuroprotective activity of GPE tripeptide analogues does not correlate with glutamate receptor binding affinity
Author/Authors
Sergio A. Alonso De Diego، نويسنده , , Marta Gutiérrez-Rodr?guez، نويسنده , , M. Jes?s Pérez de Vega، نويسنده , , Rosario Gonz?lez-Mu?iz، نويسنده , , Rosario Herranz، نويسنده , , Mercedes Mart?n-Mart?nez، نويسنده , , Edurne Cenarruzabeitia، نويسنده , , Diana Frechilla، نويسنده , , Joaqu?n Del R?o، نويسنده , , M. Luisa Jimeno، نويسنده , , M. Teresa Garc?a-L?pez، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
3396
To page
3400
Abstract
The influence of several modifications on the GPE tripeptide structure upon the binding to GluRs and on their neuroprotective effects has been studied. The results indicated that the prevention of neuronal death showed by GPE and some analogues is not directly related to their affinity at glutamate receptors.
Keywords
peptidomimetics , neuroprotection , Glutamate receptors binding , GPE , Tripeptides
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796998
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