Title of article
Synthesis and SAR of novel histamine H3 receptor antagonists
Author/Authors
Cynthia D. Jesudason، نويسنده , , Lisa S. Beavers، نويسنده , , Jeffrey W. Cramer، نويسنده , , Joelle Dill، نويسنده , , Don R. Finley، نويسنده , , Craig W. Lindsley، نويسنده , , F. Craig Stevens، نويسنده , , Robert A. Gadski، نويسنده , , Samuel W. Oldham، نويسنده , , R. Todd Pickard، نويسنده , , Christopher S. Siedem، نويسنده , , Dana K. Sindelar، نويسنده , , Ajay Singh، نويسنده , , Brian M. Watson، نويسنده , , Philip A. Hipskind، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
3415
To page
3418
Abstract
The synthesis and biological evaluation of novel tetrahydroisoquinoline, tetrahydroquinoline, and tetrahydroazepine antagonists of the human and rat H3 receptors are described. The substitution around these rings as well as the nature of the substituent on nitrogen is explored. Several compounds with high affinity and selectivity for the human and rat H3 receptors are reported.
Keywords
tetrahydroquinolines , Tetrahydroisoquinolines , Tetrahydroazepines , Histamine H3 receptor antagonist
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797002
Link To Document