Title of article
Design and synthesis of selective keto-1,2,4-oxadiazole-based tryptase inhibitors
Author/Authors
James T. Palmer، نويسنده , , Robert M. Rydzewski، نويسنده , , Rohan V. Mendonca، نويسنده , , David Sperandio، نويسنده , , Jeffrey R. Spencer، نويسنده , , Bernard L. Hirschbein، نويسنده , , Julia Lohman، نويسنده , , Jeri Beltman، نويسنده , , Margaret Nguyen، نويسنده , , Liang Liu، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
6
From page
3434
To page
3439
Abstract
Using a scaleable, directed library approach based on orthogonally protected advanced intermediates, we have prepared a series of potent keto-1,2,4-oxadiazoles designed to explore the P2 binding pocket of human mast cell tryptase, while building in a high degree of selectivity over human trypsin and other serine proteases.
Keywords
Scaleable process , Heterocycle , inhibitor , Ketoheterocycle , Selective , Pharmacokinetics , Serine protease , tryptase
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797006
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