Title of article
Privileged structure based ligands for melanocortin-4 receptors—Aliphatic piperazine derivatives
Author/Authors
Karin Briner، نويسنده , , Ivan Collado، نويسنده , , Matthew J. Fisher، نويسنده , , Cristina Garc?a-Paredes، نويسنده , , Saba Husain، نويسنده , , Steven L. Kuklish، نويسنده , , Ana I. Mateo، نويسنده , , Thomas P. O’Brien، نويسنده , , Paul L. Ornstein، نويسنده , , John Zgombick، نويسنده , , ?scar de Frutos، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
3449
To page
3453
Abstract
Aliphatic carbocyclic replacement of the benzyl group of compound 1 yielded compounds with high affinity for the melanocortin-4 receptor (MC4R). Compounds with a cyclohexyl group showed a consistent high affinity, while different polar groups with less basicity were good replacements for the original diethyl amines. Substitution of the polar group found in these privileged structures with an aliphatic moiety produced compounds with high affinity for MC4R.
Keywords
Privileged structures , Melanocortin receptors
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797009
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