Title of article
Novel 1,4-benzodiazepine-2,5-diones as Hdm2 antagonists with improved cellular activity
Author/Authors
Kristi Leonard، نويسنده , , Juan Jose Marugan، نويسنده , , Pierre Raboisson، نويسنده , , Raul Calvo، نويسنده , , Joan M. Gushue، نويسنده , , Holly K. Koblish، نويسنده , , Jennifer Lattanze، نويسنده , , Shuyuan Zhao، نويسنده , , Maxwell D. Cummings، نويسنده , , Mark R. Player، نويسنده , , Anna C. Maroney، نويسنده , , Tianbao Lu، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
6
From page
3463
To page
3468
Abstract
The disruption of the p53-Hdm2 protein–protein interaction induces cell growth arrest and apoptosis. We have identified the 1,4-benzodiazepine-2,5-dione scaffold as a suitable template for inhibiting this interaction by binding to the Hdm2 protein. Several compounds have been made with improved potency, solubility, and cell-based activities.
Keywords
Hdm2 , p53 , Benzodiazepinedione
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797012
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