Title of article
Heteroaryl substituted bis-trifluoromethyl carbinols as malonyl-CoA decarboxylase inhibitors
Author/Authors
Jie-Fei Cheng، نويسنده , , Chi Ching Mak، نويسنده , , Yujin Huang، نويسنده , , Richard Penuliar، نويسنده , , Masahiro Nishimoto، نويسنده , , Lin Zhang، نويسنده , , Chin-Mi Chen، نويسنده , , David Wallace، نويسنده , , Thomas Arrhenius، نويسنده , , Donald Chu، نويسنده , , Guang Yang، نويسنده , , Miguel Barbosa، نويسنده , , Rick Barr، نويسنده , , Jason R.B. Dyck، نويسنده , , Gary D. Lopaschuk، نويسنده , , Alex M. Nadzan، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
3484
To page
3488
Abstract
A series of heteroaryl-substituted bis-trifluoromethyl carbinols were prepared and evaluated as malonyl-CoA decarboxylase (MCD) inhibitors. Some thiazole-based derivatives showed potent in vitro MCD inhibitory activities and significantly increased glucose oxidation rates in isolated working rat hearts.
Keywords
malonyl-CoA , Acetyl-CoA , Malonyl-CoA decarboxylase , MCD , Fatty acid oxidation , Glucose oxidation
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797016
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