Title of article
Modulators of the human CCR5 receptor. Part 3: SAR of substituted 1-[3-(4-methanesulfonylphenyl)-3-phenylpropyl]-piperidinyl phenylacetamides
Author/Authors
John G. Cumming، نويسنده , , Simon J. Brown، نويسنده , , Anne E. Cooper، نويسنده , , Alan W. Faull، نويسنده , , Anthony P. Flynn، نويسنده , , Ken Grime، نويسنده , , John Oldfield، نويسنده , , John S. Shaw، نويسنده , , Emma Shepherd، نويسنده , , Howard Tucker، نويسنده , , David Whittaker، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
3533
To page
3536
Abstract
SAR and PK studies led to the identification of N-(1-{(3R)-3-(3,5-difluorophenyl)-3-[4-methanesulfonylphenyl] propyl}piperidin-4-yl)-N-ethyl-2-[4-methanesulfonylphenyl]acetamide as a highly potent and selective ligand for the human CCR5 chemokine receptor with good oral pharmacokinetic properties.
Keywords
CCR5 , Chemokine receptor , CCR5 antagonist , CCR5 modulator
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797026
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