Title of article
Synthesis and biological investigation of S-aryl-S-DABO derivatives as HIV-1 inhibitors
Author/Authors
Claudia Mugnaini، نويسنده , , Fabrizio Manetti، نويسنده , , José A. Esté، نويسنده , , Imma Clotet-Codina، نويسنده , , Giovanni Maga، نويسنده , , Reynel Cancio، نويسنده , , Maurizio Botta، نويسنده , , Federico Corelli، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
3541
To page
3544
Abstract
S-Aryl-S-DABO derivatives, a novel subclass of S-DABO anti-HIV-1 agents, were synthesized via Ullmann type reaction starting from the corresponding 2-thiouracils by the aid of microwave irradiation. The results of their evaluation as inhibitors of RT are reported together with their antiviral activity in cellular assays.
Keywords
HIV-1 , S-DABO derivatives , Pyrimidinones , microwave-assisted synthesis , RT inhibitors
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797028
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