Title of article :
Synthesis and biological investigation of S-aryl-S-DABO derivatives as HIV-1 inhibitors
Author/Authors :
Claudia Mugnaini، نويسنده , , Fabrizio Manetti، نويسنده , , José A. Esté، نويسنده , , Imma Clotet-Codina، نويسنده , , Giovanni Maga، نويسنده , , Reynel Cancio، نويسنده , , Maurizio Botta، نويسنده , , Federico Corelli، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Abstract :
S-Aryl-S-DABO derivatives, a novel subclass of S-DABO anti-HIV-1 agents, were synthesized via Ullmann type reaction starting from the corresponding 2-thiouracils by the aid of microwave irradiation. The results of their evaluation as inhibitors of RT are reported together with their antiviral activity in cellular assays.
Keywords :
HIV-1 , S-DABO derivatives , Pyrimidinones , microwave-assisted synthesis , RT inhibitors
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
