Title of article
Synthesis and antibacterial activity of nocathiacin I analogues
Author/Authors
B. Narasimhulu Naidu، نويسنده , , Margaret E. Sorenson، نويسنده , , John D. Matiskella، نويسنده , , Wenying Li، نويسنده , , Justin B. Sausker، نويسنده , , Yunhui Zhang، نويسنده , , Timothy P. Connolly، نويسنده , , Kin S. Lam، نويسنده , , Joanne J. Bronson، نويسنده , , Michael J. Pucci، نويسنده , , Hyekyung Yang، نويسنده , , Yasutsugu Ueda، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
3545
To page
3549
Abstract
Stereoselective reduction of dehydroalanine double bond in nocathiacin I afforded the primary amide 2. Enzymatic hydrolysis of the amide 2 provided the carboxylic acid 3, which upon coupling with a variety of amines furnished amides 4–32. Some of these semi-synthetic derivatives have retained very good antibacterial activity and have improved aqueous solubility.
Keywords
Antibacterial activity , Nocathiacin I
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797029
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