Author/Authors :
B. Narasimhulu Naidu، نويسنده , , Margaret E. Sorenson، نويسنده , , John D. Matiskella، نويسنده , , Wenying Li، نويسنده , , Justin B. Sausker، نويسنده , , Yunhui Zhang، نويسنده , , Timothy P. Connolly، نويسنده , , Kin S. Lam، نويسنده , , Joanne J. Bronson، نويسنده , , Michael J. Pucci، نويسنده , , Hyekyung Yang، نويسنده , , Yasutsugu Ueda، نويسنده ,
Abstract :
Stereoselective reduction of dehydroalanine double bond in nocathiacin I afforded the primary amide 2. Enzymatic hydrolysis of the amide 2 provided the carboxylic acid 3, which upon coupling with a variety of amines furnished amides 4–32. Some of these semi-synthetic derivatives have retained very good antibacterial activity and have improved aqueous solubility.
