Title of article :
2,3,7-Trisubstituted pyrazolo[1,5-d][1,2,4]triazines: Functionally selective GABAA α3-subtype agonists
Author/Authors :
Robert W. Carling، نويسنده , , Michael G.N. Russell، نويسنده , , Kevin W. Moore، نويسنده , , Andrew Mitchinson، نويسنده , , Alexander Guiblin، نويسنده , , Alison Smith، نويسنده , , Keith A. Wafford، نويسنده , , George Marshall، نويسنده , , John R. Atack، نويسنده , , Leslie J. Street، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Abstract :
Novel synthetic routes have been devised for the preparation of previously inaccessible 2,3,7-trisubstituted pyrazolo[1,5-d][1,2,4]triazines 2. These compounds are high affinity ligands for the GABAA benzodiazepine binding site and some analogues show functional selectivity for agonism at α3-containing receptors over α1-containing receptors with the lead compound being 32.
Keywords :
4]triazines , GABAA-Benzodiazepine-modulatory-site , Subtype-selective-agonists , 2
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
