Title of article
2-Aryl(pyrrolidin-4-yl)acetic acids are potent agonists of sphingosine-1-phosphate (S1P) receptors
Author/Authors
Lin Yan، نويسنده , , Richard Budhu، نويسنده , , Pei Huo، نويسنده , , Christopher L. Lynch، نويسنده , , Jeffrey J. Hale، نويسنده , , Sander G. Mills، نويسنده , , Richard Hajdu، نويسنده , , Carol A. Keohane، نويسنده , , Mark J. Rosenbach، نويسنده , , James A. Milligan، نويسنده , , Gan-Ju Shei، نويسنده , , Gary Chrebet، نويسنده , , James Bergstrom، نويسنده , , Deborah Card، نويسنده , , Suzanne M. Mandala، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
3564
To page
3568
Abstract
A series of 2-aryl(pyrrolidin-4-yl)acetic acids were synthesized and their biological activities were evaluated as agonists of S1P receptors. These analogs were able to induce lowering of lymphocyte counts in the peripheral blood of mice and were found to have good overall pharmacokinetic properties in rat.
Keywords
Immunosuppressants , S1P agonists , (Pyrrolidin-4-yl)acetic acids , Peripheral lymphocyte lowering
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797033
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