Title of article
Design, synthesis, and biological evaluation of indole derivatives as novel nociceptin/orphanin FQ (N/OFQ) receptor antagonists
Author/Authors
Yuichi Sugimoto، نويسنده , , Atsushi Shimizu، نويسنده , , Tetsuya Kato، نويسنده , , Atsushi Satoh، نويسنده , , Satoshi Ozaki، نويسنده , , Hisashi Ohta، نويسنده , , Osamu Okamoto، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
3569
To page
3573
Abstract
A novel series of 2-(1,2,4-oxadiazol-5-yl)-1H-indole derivatives as nociceptin/orphanin FQ (N/OFQ) receptor antagonists was discovered. Systematic modification of our original lead by changing the pendant functional groups, linker, heterocyclic core, and basic side chain revealed the structure–activity requirements for this novel template and resulted in the identification of more potent analog with improved potency as compared to the parent compound.
Keywords
Nociceptin , ORL-1 receptor , Indole , Antagonist , Orphanin FQ
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797034
Link To Document