Title of article
Spectroscopic studies of the interaction between quercetin and G-quadruplex DNA
Author/Authors
Hongxia Sun، نويسنده , , Yalin Tang ، نويسنده , , Junfeng Xiang، نويسنده , , Guangzhi Xu، نويسنده , , Yazhou Zhang، نويسنده , , Hong Zhang، نويسنده , , Lianghua Xu، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
3586
To page
3589
Abstract
Quercetin is a kind of flavonoid which has been proved to exhibit anti-tumor activity. The interaction modes of quercetins with monomeric and dimeric G-quadruplexes were studied by absorption, fluorescence, CD, and 1H NMR spectroscopies. The ligands were found to be stacked with terminal tetrads of monomeric G-quadruplexes by intercalation and bound to dimeric G-quadruplexes by groove binding.
Keywords
G-Quadruplex , Quercetin , Intercalating , Groove binding
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797038
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