Title of article
Structure–activity studies of oxazolidinone analogs as RNA-binding agents
Author/Authors
John Means، نويسنده , , Steven Katz، نويسنده , , Abhijit Nayek، نويسنده , , Rajaneesh Anupam، نويسنده , , Jennifer V. Hines، نويسنده , , Stephen C. Bergmeier، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
3600
To page
3604
Abstract
We have synthesized and tested a series of novel 3,4,5-tri- and 4,5-disubstituted oxazolidinones for their ability to bind two structurally related T box antiterminator model RNAs. We have found that optimal binding selectivity is found in a small group of 4,5-disubstituted oxazolidinones.
Keywords
Oxazolidinone , RNA , fluorescence
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797041
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