Title of article
Synthesis and structure–activity relationships of piperidine-based melanin-concentrating hormone receptor 1 antagonists
Author/Authors
Wen-Lian Wu، نويسنده , , Duane A. Burnett، نويسنده , , Richard Spring، نويسنده , , Li Qiang، نويسنده , , Thavalakulamgara K. Sasikumar، نويسنده , , Martin S. Domalski، نويسنده , , William J. Greenlee، نويسنده , , Kim O’Neill، نويسنده , , Brian E. Hawes، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
6
From page
3668
To page
3673
Abstract
Isosteric replacement of the urea group of lead compound 1 led to novel substituted piperidine phenylamide analogues. SAR on the electron-induced effects of various linkers as well as substituents on the phenyl rings and the piperidine nitrogen has been investigated. Many single-digit nanomolar MCH R1 antagonists have been identified from this series.
Keywords
Structure–activity relationship , Antagonist , Melanin-concentrating hormone receptor 1
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797053
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