Author/Authors :
Wen-Lian Wu، نويسنده , , Duane A. Burnett، نويسنده , , Richard Spring، نويسنده , , Li Qiang، نويسنده , , Thavalakulamgara K. Sasikumar، نويسنده , , Martin S. Domalski، نويسنده , , William J. Greenlee، نويسنده , , Kim O’Neill، نويسنده , , Brian E. Hawes، نويسنده ,
Abstract :
Isosteric replacement of the urea group of lead compound 1 led to novel substituted piperidine phenylamide analogues. SAR on the electron-induced effects of various linkers as well as substituents on the phenyl rings and the piperidine nitrogen has been investigated. Many single-digit nanomolar MCH R1 antagonists have been identified from this series.
