Title of article
Design and synthesis of orally efficacious benzimidazoles as melanin-concentrating hormone receptor 1 antagonists
Author/Authors
Wen-Lian Wu، نويسنده , , Duane A. Burnett، نويسنده , , Mary Ann Caplen، نويسنده , , Martin S. Domalski، نويسنده , , Chad Bennett، نويسنده , , William J. Greenlee، نويسنده , , Brian E. Hawes، نويسنده , , Kim O’Neill، نويسنده , , Blair Weig، نويسنده , , Daniel Weston، نويسنده , , Brian Spar، نويسنده , , Timothy Kowalski، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
3674
To page
3678
Abstract
Biaryl urea lead compound 1 was discovered earlier in our MCH antagonist program. Novel benzimidazole analogues with increased chemical stability, devoid of the potential carcinogenic liability associated with a biarylamine moiety, were synthesized and evaluated to be potent MCH R1 antagonists. Two compounds in this series have demonstrated in vivo efficacy in a rodent obesity model.
Keywords
Melanin-concentrating hormone receptor , Antagonist , obesity
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797054
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