Title of article
Design, synthesis, and SAR studies on a series of 2-pyridinylpiperazines as potent antagonists of the melanocortin-4 receptor
Author/Authors
Joe A. Tran، نويسنده , , Joseph Pontillo، نويسنده , , Beth A. Fleck، نويسنده , , Dragan Marinkovic، نويسنده , , Melissa Arellano، نويسنده , , Fabio C. Tucci، نويسنده , , Marion Lanier، نويسنده , , John Saunders، نويسنده , , Wanlong Jiang، نويسنده , , Caroline W. Chen، نويسنده , , Alan C. Foster، نويسنده , , Chen Chen، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
3693
To page
3696
Abstract
A series of 2-pyridinylpiperazines derived from β-Ala-(2,4-Cl)Phe dipeptide was synthesized for the study of their SARs and possible interactions with the MC4 receptor. Compounds such as 11k (Ki = 6.5 nM) possessed high potency.
Keywords
melanocortin , Antagonist , 2-Pyridinylpiperazine , synthesis
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797058
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