Title of article
Potent hFPRL1 (ALXR) agonists as potential anti-inflammatory agents
Author/Authors
Roland W. Bürli، نويسنده , , Han Xu، نويسنده , , Xiaoming Zou، نويسنده , , Kristine Muller، نويسنده , , Jennifer Golden، نويسنده , , Mike Frohn، نويسنده , , Matthew Adlam، نويسنده , , Matthew H. Plant، نويسنده , , Min Wong، نويسنده , , Michele McElvain، نويسنده , , Kelly Regal، نويسنده , , Vellarkad N. Viswanadhan، نويسنده , , Philip Tagari، نويسنده , , Randall Hungate، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
6
From page
3713
To page
3718
Abstract
We report the discovery of potent agonists for the human formyl-peptide-like 1 receptor (hFPRL1). These compounds did not act at a closely related receptor denoted human formyl peptide receptor (hFPR) up to 10 μM concentration. Recent studies have indicated that agonizing this receptor may promote resolution of inflammation. In an exploratory study, a novel hFPRL1 agonist showed efficacy in a mouse ear inflammation model following oral administration.
Keywords
ALXR , Pyrazolones , inflammation , G-protein-coupled receptor , hFPRL1
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797062
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