Author/Authors :
Roland W. Bürli، نويسنده , , Han Xu، نويسنده , , Xiaoming Zou، نويسنده , , Kristine Muller، نويسنده , , Jennifer Golden، نويسنده , , Mike Frohn، نويسنده , , Matthew Adlam، نويسنده , , Matthew H. Plant، نويسنده , , Min Wong، نويسنده , , Michele McElvain، نويسنده , , Kelly Regal، نويسنده , , Vellarkad N. Viswanadhan، نويسنده , , Philip Tagari، نويسنده , , Randall Hungate، نويسنده ,
Abstract :
We report the discovery of potent agonists for the human formyl-peptide-like 1 receptor (hFPRL1). These compounds did not act at a closely related receptor denoted human formyl peptide receptor (hFPR) up to 10 μM concentration. Recent studies have indicated that agonizing this receptor may promote resolution of inflammation. In an exploratory study, a novel hFPRL1 agonist showed efficacy in a mouse ear inflammation model following oral administration.
Keywords :
ALXR , Pyrazolones , inflammation , G-protein-coupled receptor , hFPRL1
