Novel class of cyclophosphamide prodrug: Cyclophosphamide spiropiperaziniums (CPSP)

A novel class of cyclophosphamide spiropiperaziniums was synthesized and evaluated for their in vivo anti-cancer activities against S180 and H22. Most of them exhibited definite activities. Especially, compounds 8b and 8k showed good anti-cancer activities, meanwhile, 8k also showed much lower toxicity than CP. Several interesting structure–activity relationships were revealed.