Title of article
Evaluations of substrate specificity and inhibition at PR/p3 cleavage site of HTLV-1 protease
Author/Authors
Hiromi Naka، نويسنده , , Kenta Teruya، نويسنده , , Jeong Kyu Bang، نويسنده , , Saburo Aimoto and Yoshifumi Nishimura، نويسنده , , Tadashi Tatsumi، نويسنده , , Hiroyuki Konno، نويسنده , , Kazuto Nosaka، نويسنده , , Kenichi Akaji، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
3761
To page
3764
Abstract
Core sequences necessary for substrate recognition and its inhibition at the PR/p3 site of HTLV-1 protease were clarified for the first time. From the cleavage rates of peptides containing a part of the PR/p3 site, a heptapeptide was found to be the minimal sequence required for substrate recognition. The use of synthetic inhibitors containing hydroxyethylamine dipeptide isostere indicated that a tetrapeptide sequence was necessary to achieve potent inhibition.
Keywords
HTLV-1 protease , inhibitor , Hydroxyethylamine dipeptide isostere , Substrate specificity
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797072
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