Markedly enhancing lipase-catalyzed synthesis of nucleoside drugs’ ester by using a mixture system containing organic solvents and ionic liquid

Eightfold higher yields and three times faster reaction rates were achieved by means of using a mixture solvent system composed of 90% acetone and 10% [BMIM]BF4 in the lipase-catalyzed regioselective synthesis of polymerizable ester of nucleoside drugs.