Title of article :
Array synthesis of progesterone receptor antagonists: 3-Aryl-1,2-diazepines
Author/Authors :
Robert W. Wiethe، نويسنده , , Eugene L. Stewart، نويسنده , , David H. Drewry، نويسنده , , David W. Gray، نويسنده , , Abdul Mehbob، نويسنده , , William J. Hoekstra، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Abstract :
New non-steroidal chemotypes are required for the development of drugs targeting the steroid hormone receptors. The parallel array synthesis of 3-aryl-1,2-diazepines employing solid-supported reagents is described. The resulting compounds demonstrated high affinity binding to the progesterone receptor.
Keywords :
progesterone receptor , Diazepine
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
