Title of article
N-Acylated sulfonamide sodium salt: A prodrug of choice for the bifunctional 2-hydroxymethyl-4-(5-phenyl-3-trifluoromethyl-pyrazol-1-yl) benzenesulfonamide class of COX-2 inhibitors
Author/Authors
Sunil Kumar Singh، نويسنده , , Saibaba Vobbalareddy، نويسنده , , Srinivasa Rao Kalleda، نويسنده , , Seshagiri Rao Casturi، نويسنده , , Ramesh Mullangi، نويسنده , , Rajagopalan Ramanujam، نويسنده , , Koteswar Rao Yeleswarapu، نويسنده , , Javed Iqbal، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
6
From page
3921
To page
3926
Abstract
Synthesis and biological evaluation of possible prodrugs of COX-2 inhibitors involving sulfonamide and hydroxymethyl groups of 2-hydroxymethyl-4-(5-phenyl-3-trifluoromethyl-pyrazol-1-yl) benzenesulfonamides are described. Out of many options, the sodium salt of N-propionyl sulfonamide demonstrated much improved pharmacological profiles and physicochemical properties suitable for oral as well as parenteral administration.
Keywords
1 , 5-Diarylpyrazoles , parenteral administration , prodrugs , COX-2 inhibitors
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797105
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