Title of article
P2–P4 Macrocyclic inhibitors of hepatitis C virus NS3-4A serine protease
Author/Authors
Ashok Arasappan، نويسنده , , F. George Njoroge، نويسنده , , Kevin X. Chen، نويسنده , , Srikanth Venkatraman، نويسنده , , Tejal N. Parekh، نويسنده , , Haining Gu، نويسنده , , John Pichardo، نويسنده , , Nancy Butkiewicz، نويسنده , , Andrew Prongay، نويسنده , , Vincent Madison، نويسنده , , Viyyoor Girijavallabhan، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
6
From page
3960
To page
3965
Abstract
Synthesis and HCV NS3 serine protease inhibitory activity of 4-hydroxyproline derived macrocyclic inhibitors and SAR around this macrocyclic core is described in this communication. X-ray structure of inhibitor 38 bound to the protease is discussed.
Keywords
HCV NS3-4A serine protease inhibitor , HCV protease inhibitor , Macrocycle , Ketoamide
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797113
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