Title of article
Synthesis and biological evaluation of type VI β-turn templated RGD peptidomimetics
Author/Authors
Christopher J. Creighton، نويسنده , , Yanming Du، نويسنده , , Rosemary J. Santulli، نويسنده , , Brett A. Tounge، نويسنده , , Allen B. Reitz، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
3971
To page
3974
Abstract
We report the design, synthesis, and binding affinities of a family of cyclic RGD peptides attached to type VI β-turn scaffolds. The analogues prepared exhibit interesting binding data to the isolated receptors αvβ3 and αvβ5. The results demonstrate the utility of these type VI β-turn scaffolds for the constraint of biologically relevant peptides.
Keywords
Beta turn , Scaffold , Peptidomimetic , RGD
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797115
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