Title of article :
Design of novel, potent, and selective human β-tryptase inhibitors based on α-keto-[1,2,4]-oxadiazoles
Author/Authors :
Chang Sun Lee، نويسنده , , Weili Liu، نويسنده , , Paul A. Sprengeler، نويسنده , , John R. Somoza، نويسنده , , James W. Janc، نويسنده , , David Sperandio، نويسنده , , Jeffrey R. Spencer، نويسنده , , Michael J. Green، نويسنده , , Mary E. McGrath and Bradley A. Katz، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Abstract :
A series of novel α-keto-[1,2,4]-oxadiazoles has been synthesized as human tryptase inhibitors for evaluation as a new class of anti-asthmatic agent. The inhibitor design is focused on using a prime-side hydrophobic pocket and the S2 pocket of β-tryptase to achieve inhibition potency and selectivity over other serine proteases.
Keywords :
Tryptase inhibitor , Activated carbonyl , Oxadiazole , asthma
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
