Title of article :
Azadideoxyadenosine: Synthesis, enzymology, and anti-HIV activity
Author/Authors :
Abdumalik A. Nishonov، نويسنده , , Xiaohui Ma، نويسنده , , Vasu Nair، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Abstract :
Synthesis of an azanucleoside, a new analogue of dideoxyadenosine, is described. This compound is only slowly deaminated by mammalian adenosine deaminase and it is a substrate for adenosine kinase. It exhibits in vitro anti-HIV activity.
Keywords :
Azanucleoside , Anti-HIV activity , adenosine deaminase , synthesis , kinase phosphorylation
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
